Why the study?
Does nitric oxide synthase blockade with L-NMMA reduce flow-mediated dilatation in the superficial femoral artery in healthy men and spinal cord-injured individuals?
Population
14 individuals, comprising 8 healthy men and 6 spinal cord-injured individuals.
Comparison
Infusion of the nitric oxide synthase blocker… vs Infusion of saline
Design
Other
Authors
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Reinforces NO mediation of femoral FMD even in deconditioned limbs; extends mechanistic data but leaves open clinical translation.
Does nitric oxide synthase blockade with L-NMMA reduce flow-mediated dilatation in the superficial femoral artery in healthy men and spinal cord-injured individuals?
Superficial femoral artery flow-mediated dilatation in response to 5 minutes of occlusion is predominantly mediated by nitric oxide in both healthy men and extremely deconditioned legs of SCI individuals.
Kooijman et al. (2007) studied this question.
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