Why the study?
Although prognostic significance has been shown for some BP variability indicators, the clinical significance and utility of measuring BP variability beyond absolute BP values remain uncertain.
Does blood pressure variability redefine cardiovascular risk beyond absolute blood pressure values in hypertensive patients?
Does blood pressure variability redefine cardiovascular risk beyond absolute blood pressure values in hypertensive patients?
Absolute blood pressure values remain the most relevant risk factor for cardiovascular risk definition, rather than blood pressure variability.
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Absolute BP remains central to CV risk stratification in hypertension; leaves open whether refined variability metrics add value in prospective studies.
(>5 years). Accurate measurement of BP variability represents a complex and often controversial endeavour, despite several methodological approaches are available. Albeit a prognostic significance has been demonstrated for some indicators of BP variability, the clinical significance of this measurement is still uncertain. In fact, none of the indicators presently available for BP variability, including early morning BP rise, substantially affects, and redefines, the cardiovascular risk of the hypertensive patient, over and beyond the mere BP values. Accordingly, in defining the cardiovascular risk, the focus should be on the absolute BP values, which remain the most relevant risk factor, and the one more susceptible to modification with both non-pharmacologic and pharmacologic treatment.
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Rosei et al. (2020) studied this question.
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