Why the study?
AF and VTE are highly prevalent in CKD, and evidence was needed on the use of DOACs compared with warfarin in this population.
Do DOACs improve efficacy and safety outcomes compared to warfarin in patients with chronic kidney disease and atrial fibrillation or VTE?
Population
Patients with CKD and atrial fibrillation or VTE
Comparison
DOACs vs warfarin or VKAs
Design
Review article
Authors
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May favor DOACs over warfarin in moderate CKD; leaves open anticoagulation benefit in dialysis given high bleeding and warrants RCTs.
Do DOACs improve efficacy and safety outcomes compared to warfarin in patients with chronic kidney disease and atrial fibrillation or VTE?
DOACs are preferred over warfarin in moderate-to-severe CKD with appropriate dose adjustment, but current evidence questions the need for oral anticoagulation in maintenance dialysis patients due to high bleeding risks.
Elenjickal et al. (2023) studied this question.
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