Why the study?
Does recombinant human thrombomodulin reduce in-hospital mortality in adult mechanically ventilated patients with sepsis-induced DIC?
Population
162 adult patients with sepsis-induced disseminated intravascular coagulation who required ventilator…
Comparison
Recombinant human thrombomodulin (rhTM) vs No rhTM treatment
Design
Cohort
Follow-up
in-hospital
Authors
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Hypothesis-generating for rhTM in ventilated sepsis-DIC; RCTs needed before any practice change.
Does recombinant human thrombomodulin reduce in-hospital mortality in adult mechanically ventilated patients with sepsis-induced DIC?
Recombinant human thrombomodulin may be associated with reduced in-hospital mortality in adult mechanically ventilated patients with sepsis-induced DIC without increasing bleeding complications.
Yamakawa et al. (2013) studied this question.
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