What question did this study set out to answer?

To investigate the natural history, survival outcomes, and prognostic factors associated with recurrent hepatocellular carcinoma after liver transplantation.

March 23, 2004Liver Transplantation

Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

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Authors

SRSasan RoayaieWhite Plains Hospital JSJonathan D. SchwartzEternity Bioscience (United States)MSMax W. SungIcahn School of Medicine at Mount Sinai

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Implication

Retrospective cohort study reveals reduced survival following hepatocellular carcinoma recurrence after liver transplant, highlighting surgical resection for improved outcomes.

Key Points

To investigate the natural history, survival outcomes, and prognostic factors associated with recurrent hepatocellular carcinoma after liver transplantation.
Retrospective review of adult patients undergoing liver transplantation between September 19, 1988, and September 19, 2002.
Identified 311 patients with histologically confirmed hepatocellular carcinoma in the explanted liver, analyzing those who developed post-transplant recurrence.
Evaluated overall survival from transplantation and from recurrence relative to recipient demographics, surgical technique, tumor pathology, and treatments.
Tumor recurrence occurred in 57 of 311 patients (18.3%) at a median time of 12.3 months.
Five-year survival was significantly worse in patients with recurrence compared to those without recurrence (22% vs. 64%, P < 0.0001).
Multivariate analysis showed that absence of bone metastases, recurrence developing more than 12 months post-transplant, and surgical treatment of recurrence independently predicted significantly prolonged survival after recurrence.

Cite This Study

Roayaie et al. (2004) studied this question.

synapsesocial.com/papers/6a03fe41ac14ad449f2b3741 https://doi.org/10.1002/lt.20128

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Implication

Retrospective cohort study reveals reduced survival following hepatocellular carcinoma recurrence after liver transplant, highlighting surgical resection for improved outcomes.

Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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