Design, synthesis and biological evaluation of novel chalcone-derived thioxopyridine and pyrazolopyridine compounds as antimicrobial agents

C-NMR and MS spectral studies. All the newly synthesized compounds were evaluated for their in vitro antibacterial activity against S. aureus as example of Gram-positive bacteria and E. coli as example of Gram-negative bacteria. They were also evaluated for their in vitro antifungal potential effect against C. albicans. The zone of inhibition was measured using the well diffusion assay, and the results indicated that compounds 3, 5, 10 and 13 showed potential antibacterial and antifungal effects.