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May 7, 2026Annals of the American Thoracic Society

High cytomegalovirus antibody concentrations and lower lung function in persons with HIV who smoke

Jeppe T Christiansen Anna K H Roed Nicoline Arentoft Thomas Benfield Moises Alberto Suarez‐Zdunek Sisse Rye Ostrowski Nikolai Kirkby Andreas Dehlbæk Knudsen Safura-Luise Heidari Ken M Kunisaki Susanne D Nielsen

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Key Points

Investigate the relationship between CMV IgG concentrations and lung function in persons with HIV who smoke.
Included persons with HIV aged 25+ from the COCOMO study with viral suppression.
Measured CMV IgG concentrations via indirect chemiluminescent immunoassay.
Assessed lung function using spirometry to measure FEV1.
In 987 persons with HIV, 33% had high CMV IgG concentrations.
High CMV IgG concentrations were associated with lower FEV1 by -86.7 mL (95% CI: -164.5; -8.9, P = .029).
The effect was more severe in current smokers with a reduction of -292.8 mL (95% CI: -446.5; -139.0, P < .001).

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Implication

Shows CMV IgG concentrations linked to lower lung function in individuals with HIV, suggesting health risks for smokers.

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Cite This Study

Christiansen et al. (2026) studied this question.

synapsesocial.com/papers/6a04147679e20c90b4444747 https://doi.org/10.1093/annalsats/aaoag121

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