Flavonoids from Elsholtzia ciliata restore redox electron flow and metabolic signaling via PTP1B inhibition in muscle and liver cells

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Key Points

This research aims to explore how flavonoids from Elsholtzia ciliata can enhance redox electron flow and metabolic signaling by inhibiting PTP1B.
Investigated the effects of flavonoids on muscle and liver cells.
Analyzed the role of PTP1B inhibition in metabolic signaling pathways.
Assessed improvements in insulin resistance markers.
Flavonoid treatment significantly improved metabolic signaling in muscle cells (p<0.05).
PTP1B inhibition correlated with enhanced insulin sensitivity in liver cells (p<0.01).
Overall improvement in redox state was observed in both cell types after flavonoid treatment.

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Shows restoration of metabolic signaling in muscle and liver cells, suggesting a role in managing insulin resistance.

, highlighting their potential for insulin resistance and metabolic syndrome.

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Lee et al. (2026) studied this question.

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