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December 11, 2025Scientific ReportsOpen Access

Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathway

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Authors

JTJing TaoSLSiqi LiuYLYunzhi Ling

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Overview

Cirsiliol improves cardiac function in diabetic cardiomyopathy by reducing oxidative stress and inflammation, indicating potential therapeutic benefits.

Key Points

  • Investigate how Cirsiliol affects diabetic cardiomyopathy and its mechanisms of action.
  • Utilized a high-glucose-treated H9C2 myocardial cell model
  • Employed a streptozotocin-induced diabetic mouse model
  • Examined the activation of the PPAR-α/AMPK pathway
  • Measured levels of malondialdehyde and superoxide dismutase activity
  • Cirsiliol increased myocardial cell survival
  • Inhibited high-glucose-induced apoptosis
  • Improved cardiac function in diabetic mice
  • Activated PPAR-α/AMPK pathway
  • Reduced lipid peroxidation and inflammatory factors like IL-6 and TNF-α

Cite This Study

Tao et al. (2025) studied this question.

synapsesocial.com/papers/69401b0d2d562116f28f71a0https://doi.org/10.1038/s41598-025-32157-w
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