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March 28, 2025Journal of Cardiovascular Pharmacology

Cinnamaldehyde alleviated diabetic cardiomyopathy in rats by modulating the AMPK-α2/PPAR-α/PGC-1α signaling pathway to restore energy metabolism and activating autophagy through the mTOR pathway.

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Why the study?

Diabetic cardiomyopathy can lead to heart failure, and this study aimed to explore the cardioprotective role and mechanisms of cinnamaldehyde on diabetic cardiomyopathy.

Does cinnamaldehyde attenuate diabetic cardiomyopathy in STZ-induced diabetic rats?

Population

Streptozotocin-induced diabetic rats

Comparison

Cinnamaldehyde (50 mg/kg daily)

Design

Animal experimental study

Follow-up

28 days

Key result

Cinnamaldehyde alleviated diabetic cardiomyopathy in rats by modulating the AMPK-α2/PPAR-α/PGC-1α signaling pathway to restore energy metabolism and activating autophagy through the mTOR pathway.

Authors

MHMengting HuKWKe‐Zhao WeiSWShiyu Wu

Discussion

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Member takes

Overview

CA attenuates DCM in STZ rats; hypothesis-generating for human translation.

Structured PICO

Does cinnamaldehyde attenuate diabetic cardiomyopathy in STZ-induced diabetic rats?

P
Population
Diabetic rats established by injection of streptozotocin treated with Cinnamaldehyde for 28 days.
I
Intervention
Cinnamaldehyde (CA) 50 mg/kg administered via gavage daily for 28 days
O
Outcome
Cardiac histopathological alterations, hypertrophy, BNP level, ECG intervals, and myocardial energy metabolismsurrogate

In a rat model of diabetic cardiomyopathy, cinnamaldehyde attenuated cardiac injury by restoring energy metabolism and activating autophagy.

Cite This Study

Hu et al. (2025) studied Diabetic Cardiomyopathy. Cinnamaldehyde was evaluated on Energy metabolism disturbance and autophagy activation. Cinnamaldehyde alleviated diabetic cardiomyopathy in rats by modulating the AMPK-α2/PPAR-α/PGC-1α signaling pathway to restore energy metabolism and activating autophagy through the mTOR pathway.

synapsesocial.com/papers/6a7c7ff6f78cd83d7f8f13cdhttps://doi.org/10.1097/fjc.0000000000001694
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cinnamon Polyphenols Ameliorate the Dysregulation of Cardiac Energy and Autophagic Homeostasis in Rats with Diabetic Cardiomyopathy via the mTOR/PGC1α Pathway2024 · 1 citations
  2. 2Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti‐inflammatory, anti‐dyslipidemia, and antidiabetic properties2022 · 35 citations
  3. 3Diabetic cardiomyopathy was attenuated by cinnamon treatment through the inhibition of fibro‐inflammatory response and ventricular hypertrophy in diabetic rats2022 · 24 citations
  4. 4Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathway2025
  5. 5Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes2025 · 13 citations