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September 18, 2022Journal of Biochemical and Molecular Toxicology

Oral administration of cinnamic acid (5 and 10 mg/kg bwt) prevented the development of diabetic cardiomyopathy via cardioprotective, anti-inflammatory, anti-dyslipidemia, and antidiabetic properties.

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Why the study?

Diabetic cardiomyopathy is an increasing health issue with a lack of proper management strategies, prompting investigation of a nutraceutical-based approach.

Does oral administration of cinnamic acid prevent the development of diabetic cardiomyopathy in a rat model of diabetes?

Population

Male Wistar rats fed a high fat, high fructose diet and single-dose streptozotocin

Comparison

Oral cinnamic acid (5 and 10 mg/kg bwt) vs metformin (50 mg/kg bwt) vs controls

Design

Animal experimental study

Authors

ANAnupama NairGlan Clwyd HospitalMRM.R. Preetha RaniNational Institute for Interdisciplinary Science and TechnologySRS. RanjitJubilee Mission Medical College and Research Institute

Discussion

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Overview

Cinnamic acid may attenuate diabetic cardiomyopathy in rats; leaves open translation to human therapy.

Structured PICO

Does oral administration of cinnamic acid prevent the development of diabetic cardiomyopathy in a rat model of diabetes?

P
Population
Male Wistar rats fed a high fat, high fructose diet for 6 months and a single dose of streptozotocin (25 mg/kg bwt) to create a diabetic cardiomyopathy model
I
Intervention
Oral administration of cinnamic acid (5 and 10 mg/kg bwt)
C
Comparator
Untreated diabetic rats and metformin (50 mg/kg bwt) as a positive control
O
Outcome
Development of diabetic cardiomyopathy assessed via cardiac mass index, cardiac injury markers (LDH, CKMB, ANP, CRP), hypertrophy markers (TGF-β, β-MHC), inflammatory cytokines (TNF-α, IL-6), lipid peroxides, and histopathologysurrogate

Cinnamic acid demonstrates potential as a nutraceutical approach for preventing diabetic cardiomyopathy in a preclinical rat model.

Cite This Study

Nair et al. (2022) studied this question.

synapsesocial.com/papers/6a9539fda7ac13952db2c664https://doi.org/10.1002/jbt.23215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cinnamaldehyde Attenuates Diabetic Cardiomyopathy by Ameliorating Energy Metabolism Disturbance and Activating Autophagy2025 · 5 citations
  2. 2Diabetic cardiomyopathy was attenuated by cinnamon treatment through the inhibition of fibro‐inflammatory response and ventricular hypertrophy in diabetic rats2022 · 24 citations
  3. 3Cardioprotective role of diacerein in diabetic cardiomyopathy via modulation of inflammasome/caspase1/interleukin1β pathway in juvenile rats2024 · 8 citations
  4. 4Protective role of cichoriin and inulin against HFD-STZ-induced diabetic cardiomyopathy in mice via oxidative stress suppression and metabolic modulation2026 · 4 citations
  5. 5Icariin Attenuates Diabetic Cardiomyopathy and Downregulates Extracellular Matrix Proteins in Heart Tissue of Type 2 Diabetic Rats2020 · 23 citations