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January 15, 2024Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Cardioprotective role of diacerein in diabetic cardiomyopathy via modulation of inflammasome/caspase1/interleukin1β pathway in juvenile rats

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Why the study?

Diabetic cardiomyopathy is a serious complication of diabetes mellitus, motivating the search for cardioprotective agents like diacerein and exploration of mediating mechanisms including the inflammasome/caspase1/interleukin1β pathway.

Does diacerein improve diabetic cardiomyopathy parameters in juvenile rats with type 1 diabetes?

Population

Four-week-aged juvenile rats

Comparison

Control vs diacerein vs diabetic vs diabetic-treated groups

Design

Randomized preclinical animal study

Follow-up

6 weeks

Authors

MRMarwa Monier Mahmoud RefaieHMHanaa Hassanein MohammedEAElshymaa A. Abdel‐Hakeem

Discussion

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Overview

Diacerein effects in rat diabetic cardiomyopathy warrant human trials; leaves open clinical efficacy and safety.

Structured PICO

Does diacerein improve diabetic cardiomyopathy parameters in juvenile rats with type 1 diabetes?

P
Population
Four-week-aged juvenile rats with streptozotocin (45 mg/kg i.p.) induced type 1 diabetes
I
Intervention
Diacerein 50 mg/kg/day for 6 weeks
C
Comparator
Untreated diabetic rats and non-diabetic control rats
O
Outcome
Diabetic cardiomyopathy changes including inflammatory, apoptotic, and oxidative stress parameters, cardiac enzymes, heart weights, fasting blood glucose, HbA1c, and blood pressuresurrogate

Diacerein demonstrates cardioprotective effects against diabetic cardiomyopathy in a juvenile rat model via modulation of the inflammasome/caspase1/interleukin1β pathway.

Cite This Study

Refaie et al. (2024) studied this question.

synapsesocial.com/papers/6a82c2469192075d3cd4b4ffhttps://doi.org/10.1007/s00210-023-02921-8
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Also Consider

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  1. 1Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti‐inflammatory, anti‐dyslipidemia, and antidiabetic properties2022 · 35 citations
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  4. 4Cardioprotective Effects of Dorzagliatin Against Streptozotocin-induced Diabetic Cardiomyopathy: Involvement of Anti-hyperlipidemic, Antioxidant, and Anti-inflammatory Mechanisms2026
  5. 5Cinnamaldehyde Attenuates Diabetic Cardiomyopathy by Ameliorating Energy Metabolism Disturbance and Activating Autophagy2025 · 5 citations