Rapid trial demonstrates effective detection of bongkrekic acid in urine, suggesting a new tool for toxin monitoring.
of 0.64 ng/mL and a limit of detection of 0.12 ng/mL, representing a 10-fold improvement over the ic-ELISA using conventional conjugates and providing a performance comparable to LC-MS/MS. The method was successfully validated in spiked blind urine samples, highlighting its applicability in clinically relevant matrices. The combination of BA-MBP fusion conjugate with photonic biosensing establishes a robust, safe, and scalable approach for rapid, reliable BA detection and quantification, with strong potential for point-of-care diagnostics and decentralized toxin monitoring.
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Cao et al. (2026) studied this question.
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