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This study aims to evaluate the protective effects of 4-hexylresorcinol against ethanol-induced liver and pancreatic injury.

May 13, 2026BiomedicinesOpen Access

4-Hexylresorcinol Attenuates Ethanol-Induced Hepatic and Pancreatic Injury by Modulating Metabolic Dysfunction and Endoplasmic Reticulum Stress

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Randomized trial demonstrates 4-hexylresorcinol reduces liver and pancreas injury in mice, suggesting potential for multi-organ protection.

This study aims to evaluate the protective effects of 4-hexylresorcinol against ethanol-induced liver and pancreatic injury.
Male C57BL/6J mice (6 weeks old) were randomized into four groups (n=10 per group): control, EtOH, EtOH + 4HR (5 mg/kg), and EtOH + 4HR (10 mg/kg).
Mice were fed a liquid ethyl alcohol diet for 5 weeks, followed by assessments of glucose tolerance, fasting glucose, and serum insulin levels.
Histological and biochemical analyses were performed on liver and pancreas tissues to evaluate injury and inflammation.
Chronic ethanol exposure led to impaired glucose homeostasis and significant increases in hepatic inflammation, evidenced by elevated ALT levels.
4HR administration (10 mg/kg) significantly reduced hepatic inflammatory changes and ALT elevation, and decreased pancreatic malondialdehyde levels.
GADD153 (CHOP) expression was reduced in both liver and pancreas following 4HR treatment, indicating modulation of endoplasmic reticulum stress.

Rotar et al. (2026) studied this question.

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Randomized trial demonstrates 4-hexylresorcinol reduces liver and pancreas injury in mice, suggesting potential for multi-organ protection.