Effect of vaginal estrogen supplementation for luteal phase support in the GnRH antagonist protocol on pregnancy outcomes for IVF/ICSI cycles: a randomized controlled trial

View Full Paper

Ask AI

Bookmark

Share

Key Points

This trial investigates if adding vaginal estradiol to progesterone improves pregnancy outcomes in IVF/ICSI cycles using GnRH antagonist protocol.
518 women aged 20-39 randomized to receive progesterone alone or progesterone plus vaginal estradiol for luteal phase support.
Luteal support commenced on day 1 post-oocyte retrieval; groups received either vaginal progesterone + dydrogesterone or vaginal progesterone + estradiol nightly.
Primary outcome assessed was ongoing pregnancy rates, with secondary outcomes including clinical pregnancy and live birth rates.
Ongoing pregnancy rates were 46.33% in the E + P group vs. 39.00% in the P group (P=0.091).
Clinical pregnancy rates were significantly higher in the E + P group at 53.28% vs. 44.02% (P=0.035).
Live birth rates showed no significant between-group differences, with increased risk of intrahepatic cholestasis of pregnancy in the E + P group (5.17% vs. 0%, P=0.032).

We only have this paper's title and publication details.

Answers are grounded in this paper and cite their sources.

Randomized trial examines vaginal estradiol alongside progesterone for IVF/ICSI, suggesting potential improvements in early pregnancy outcomes.

No takes yet. Share an insight, caveat, or question.

Yang et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share