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May 13, 2026Egyptian Rheumatology and RehabilitationOpen Access

Effectiveness of Early Botulinum Toxin Injections on Upper Limb Spasticity versus after 6 months post stroke

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Authors

AAAhmed Gamal AbdelmoneamArmed Forces College of MedicineHDH.Z. DarwishCairo UniversityAAAhmed Essmat AliAl-Azhar University

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Implication

Randomized trial evaluates early versus late botulinum toxin interventions on spasticity in stroke patients, suggesting improved outcomes with early treatment.

Key Points

  • This research aims to compare the effectiveness of early versus late Botulinum toxin injections on upper limb spasticity in post-stroke patients.
  • Conducted an interventional study with 60 patients experiencing post-stroke upper-limb spasticity.
  • Evaluated spasticity using the modified Ashworth scale and functional status with the Barthel Index and UL-MAS.
  • Patients received either early injections within 3 months or late injections 6 months post-stroke, followed by rehabilitation.
  • Both groups showed significant improvements in modified Ashworth and disability assessment scales (P < 0.001).
  • Group I demonstrated superior improvements in all scales post-injection compared to Group II (P < 0.05).
  • Early injection patients reported better global assessments from patients, physicians, and caregivers (P < 0.001).

Cite This Study

Abdelmoneam et al. (2026) studied this question.

synapsesocial.com/papers/6a0415aa79e20c90b44455dfhttps://doi.org/10.1186/s43166-026-00411-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interrater Reliability of a Modified Ashworth Scale of Muscle Spasticity1987 · 5,477 citations
  2. 2Early AbobotulinumtoxinA (Dysport®) in Post-Stroke Adult Upper Limb Spasticity: ONTIME Pilot Study2018 · 51 citations
  3. 3Effectiveness of AbobotulinumtoxinA in Post-stroke Upper Limb Spasticity in Relation to Timing of Treatment2020 · 31 citations
  4. 4Early Botulinum Toxin Type A Injection May Improve Motor Recovery in Patients with Post-Stroke Spasticity: A Secondary Analysis from a Longitudinal Cohort Study2025 · 7 citations
  5. 5Early Botulinum Toxin Type A Injection for Post-Stroke Spasticity: A Longitudinal Cohort Study2021 · 46 citations