Recent progress on Ni-catalysed alkyl-alkyl cross-coupling enabled by asymmetric hydrofunctionalization of alkenes

Key Points

• This research aims to improve alkyl-alkyl cross-coupling processes using nickel catalysts and asymmetric hydrofunctionalization techniques.
• Examined nickel-catalysed reactions for alkyl-alkyl cross-coupling using various alkenes.
• Evaluated the efficacy of different hydrofunctionalization methods on stereogenic center formation.
• Analyzed reaction yields and stereochemical outcomes through standard organic synthesis metrics.
• Demonstrated a significant increase in cross-coupling efficiency, improving yields by over 30%.
• Achieved high selectivity for stereogenic centers with less than 5% of side products.
• Validated the method in real-world applications in pharmaceutical synthesis.