To study the effect of the aqueous extract of Atriplex hortēnsis L. on adaptation to physical and stress loads in an in vivo model

Plant raw materials contain physiologically active secondary metabolites that help our body neutralize the negative impact of adaptation syndrome. The purpose of the studyis to study the effect of Atriplex hortēnsis L. on the formation of a compensatory-adaptive mechanism of body de-fense during physical activity in combination with a stress factor. Results. The chemical composition of Atriplex hortēnsis L. has been studied: the percentage of crude protein is (33.55 ± 0.65) %, the mass fraction of reducing sugars is (0.92 ± 0.02) %, the mass fraction of crude ash is (19.24 ± 0.36) %, minerals (calcium – (2.53 ± 0.04) %, phosphorus – (0.37 ± 0.01) %, iron – (0.0160 ± 0.0003) %, copper – (0.430 ± 0.008) mg/kg, zinc – (6, 83 ± 0.14) mg/kg), mass fraction of tannins – (3.74 ± 0.05) %, antioxidant activity – (0.37 ± 0.01) mmol-eq/l. In an in vivo model, the effect of an aqueous extract of Átriplex hortēnsis L. in various concentrations on increasing performance and nonspecific resistance in female Wistar rats exposed to physical and stress loads (simulated running loads, swimming and exposure to low temperatures) was studied. By the 30th day, the fatigue of rats with the administration of quinoa extract decreases compared to rats receiving water by 45.3; 53.5; 57 % with increasing dosage of the extract. The use of Átriplex hortēnsis L. extract by animals with cold stress, even at the lowest concentration, improves the performance of rats in the run-to-failure test. Prevents the accumulation of lipid peroxidation products. in the lung tissue of animals exposed to chronic cold stress, the content of highly toxic secondary products of lipid peroxidation – hydroperoxides (reduction by 2.1–2.6 times depending on the dose of the extract), diene conjugates (reduction by up to 68 %), Histological studies of experimental rats groups showed changes in the myocardium, compensatory-adaptive reactions develop aimed at improving transcapillary metabolism and stimulating the biosynthesis of contractile and energy-producing structures, which indicates the prospects and feasibility of using Atriplex hortensis L. as a source of phytoadaptogens.