Serum endocan levels were independently and negatively associated with cardiovascular risk score (B -0.007, p=0.030) in disease-free young women.
Cross-Sectional (n=129)
In young, disease-free women, serum endocan levels are independently associated with cardiovascular risk scores, suggesting its potential utility as an early biomarker for subclinical atherosclerosis.
Effect estimate: B -0.007 (95% CI -0.014 to -0.001)
p-value: p=0.030
Cardiovascular disease (CVD) is a major cause of death in the female population. The current study aimed to examine the relationship between CVD risk and novel endothelial dysfunction biomarkers i.e., endocan, adiponectin and intercellular adhesion molecule (ICAM)-1 and carotid intima-media thickness (cIMT), respectively in a cohort of disease-free women of reproductive age. A total of 129 women were selected. Serum endocan, adiponectin and ICAM-1 were measured by a commercial enzyme-linked immunosorbent assay and cITM was determined by ultrasound. Cardiovascular risk score (CVRS) was calculated. The lowest endocan (p for trend = 0.051) and adiponectin (p for trend = 0.040) levels were found in a group of subjects with the highest CVRS. The cIMT values were the highest in second tertile subgroups, with the highest 75th percentile in a third tertile CVRS group, while the lowest cIMT values were detected in the lowest CVRS tertile group (p for trend = 0.001). A significant positive correlation between cIMT and CVRS (ρ = 0.307, p < 0.001), and a negative correlation between adiponectin and endocan with CVRS, respectively (ρ = - 0.252, p = 0.004; ρ = - 0.179, p = 0.043) were observed, but only endocan retained the independent association with CVRS (p = 0.030) in the multiple linear regression analysis. Endocan could be useful diagnostic tool in the estimation of cardiovascular risk in young women.
Klisić et al. (Mon,) conducted a cross-sectional in Disease-free young women (n=129). Endothelial dysfunction biomarkers (endocan, adiponectin, ICAM-1) was evaluated on Independent association of endocan with Cardiovascular Risk Score (CVRS) in multiple linear regression (B -0.007, 95% CI -0.014 to -0.001, p=0.030). Serum endocan levels were independently and negatively associated with cardiovascular risk score (B -0.007, p=0.030) in disease-free young women.