Key result
Lower hemoglobin glycation index linked to higher mortality in critically ill MI patients.
Why the study?
The prognosis of critically ill patients with MI is associated with metabolic disturbances, and the hemoglobin glycation index has been linked to adverse outcomes in critically ill populations, but its relationship in critically ill MI patients required exploration.
Does a low hemoglobin glycation index (HGI) predict increased all-cause mortality in critically ill patients with myocardial infarction?
Cohort (n=2,480)
Does a low hemoglobin glycation index (HGI) predict increased all-cause mortality in critically ill patients with myocardial infarction?
In critically ill patients with myocardial infarction, a low hemoglobin glycation index is independently associated with increased short- and long-term all-cause mortality.
Low HGI signals higher mortality risk in critically ill MI; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND AND AIM: The prognosis of critically ill patients with myocardial infarction (MI) is associated with metabolic disturbances. The hemoglobin glycation index (HGI), a marker of glycemic variability, has been linked to adverse outcomes in critically ill populations. This study aimed to explore the relationship between HGI and adverse outcomes in critically ill MI patients. METHODS AND RESULTS: This retrospective cohort study used data from the MIMIC-IV database, focusing on critically ill MI patients. Linear regression was applied to model the relationship between glucose and HbA1c, from which HGI values were calculated. Patients were grouped into quartiles based on HGI. Primary outcomes included 30-day, 180-day, and 365-day all-cause mortality. Kaplan-Meier survival analysis, logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analysis were employed to assess the relationship between HGI and adverse outcomes. A total of 2480 patients were included. Lower HGI was associated with significantly increased risks of 30-day, 180-day, 365-day, and hospital all-cause mortality. RCS analysis revealed an inverse J-shaped relationship between HGI and mortality risk. CONCLUSIONS: Low HGI in critically ill MI patients is significantly associated with higher all-cause mortality, highlighting its potential as a prognostic marker for early risk stratification and management optimization.
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Cao et al. (2025) conducted a cohort in Critically ill patients with myocardial infarction (n=2,480). Hemoglobin glycation index (HGI) vs. Higher HGI quartiles was evaluated on 30-day, 180-day, and 365-day all-cause mortality. A lower hemoglobin glycation index was significantly associated with higher 30-day, 180-day, and 365-day all-cause mortality in a cohort of 2480 critically ill patients with myocardial infarction.
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