Key result
Administration of surgical antimicrobial prophylaxis within 30 minutes prior to incision was associated with a 1.6% risk of surgical site infection compared with 2.4% when given 31-60 minutes prior.
Why the study?
Does administration of surgical antimicrobial prophylaxis within 30 minutes prior to incision reduce the risk of surgical site infections compared to longer intervals?
Population
4,472 randomly selected cardiac, hip/knee arthroplasty, and hysterectomy cases across 29 hospitals
Comparison
Surgical antimicrobial prophylaxis administered… vs Surgical antimicrobial prophylaxis administered…
Design
Cohort
Authors
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Supports timing prophylaxis within 30 minutes of incision; leaves open confirmation in randomized trials.
Observational (n=4,472)
Yes
Does administration of surgical antimicrobial prophylaxis within 30 minutes prior to incision reduce the risk of surgical site infections compared to longer intervals?
Effect estimate: OR 1.74 (95% CI 0.98-3.04)
Absolute Event Rate: 1.6% vs 2.4%
p-value: p=0.04
Administration of antimicrobial prophylaxis with short infusion times within 30 minutes prior to surgical incision is associated with a trend toward a lower risk of surgical site infections.
Steinberg et al. (2009) conducted an observational in Surgical site infections (n=4,472). Antimicrobial prophylaxis within 30 minutes prior to incision vs. Antimicrobial prophylaxis 31 to 60 minutes prior to surgery was evaluated on Surgical site infections (SSI) (OR 1.74, 95% CI 0.98-3.04, p=0.04). Administration of surgical antimicrobial prophylaxis within 30 minutes prior to incision was associated with a 1.6% risk of surgical site infection compared with 2.4% when given 31-60 minutes prior.
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