What question did this study set out to answer?

To investigate the complete genome sequence of uropathogenic Escherichia coli strain CFT073 and its genetic divergence relative to other strains.

Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli

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Genome sequencing uncovers unique gene compositions in uropathogenic E. coli strains, suggesting independent evolution of pathotypes.

To investigate the complete genome sequence of uropathogenic Escherichia coli strain CFT073 and its genetic divergence relative to other strains.
Conducted a three-way genome comparison involving CFT073, EDL933, and MG1655 strains.
Analyzed gene presence, including pathogenicity islands and gene encoding for fimbrial adhesins and other systems.
Examined the synteny of vertically evolved genes and identified horizontal gene transfer events.
Only 39.2% of proteins are shared among the three strains analyzed.
CFT073 lacks genes for type III secretion and certain toxins found in other E. coli strains, indicating differences in disease potential.
Distinct differences in pathogenicity islands were observed, suggesting independent evolutionary paths for extraintestinal pathogenic E. coli.

Welch et al. (2002) studied this question.

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