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January 28, 2019Journal of Lipid ResearchOpen Access

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity

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Why the study?

ANGPTL8 was previously reported to require ANGPTL3 to inhibit LPL, but the mechanism by which it controls LPL activity remained to be clarified.

Population

In vitro refolded ANGPTL8, ANGPTL3, ANGPTL4, and LPL proteins

Comparison

ANGPTL8 complexed with ANGPTL3 or ANGPTL4 vs ANGPTL4 alone

Design

In vitro mechanistic study

Authors

OKOleg KovrovUmeå UniversityKKKristian Kølby KristensenUniversity of CopenhagenELErika LarssonUppsala University

Discussion

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Implication

Does not support clinical ANGPTL8 targeting; leaves open its role as LPL regulator pending human studies.

Structured PICO

P
Population
In vitro protein models (ANGPTL8, ANGPTL3, ANGPTL4, and lipoprotein lipase)
I
Intervention
Complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4
C
Comparator
ANGPTL4 alone or ANGPTL3 alone
O
Outcome
Lipoprotein lipase (LPL) activity and inactivation mechanismsurrogate

ANGPTL8 acts as a metabolic switch by forming complexes with ANGPTL3 or ANGPTL4 to regulate lipoprotein lipase activity and direct triglyceride energy flow.

Cite This Study

Kovrov et al. (2019) studied this question.

synapsesocial.com/papers/6a0510e2fba2ba61ab55fa1ehttps://doi.org/10.1194/jlr.m088807
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding2016 · 121 citations
  2. 2Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism2005 · 434 citations
  3. 3The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure2017 · 57 citations
  4. 4Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis2018 · 141 citations
  5. 5GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 42009 · 125 citations