Why the study?
Therapeutic hypothermia requires early initiation after hypoxia-ischaemia, but identifying the timing and severity of injury remains challenging.
Do early changes in heart rate variability and heart rate patterns indicate the severity of acute hypoxia-ischaemia in near-term fetal sheep?
Population
Chronically instrumented fetal sheep at 0.85 gestational age
Comparison
Mild (n = 6), moderate (n = 8), or severe HI (n = 8) vs sham occlusion (n = 5)
Design
Animal experimental study
Follow-up
72 h
Authors
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Sinusoidal HR patterns and vasopressin may flag severe fetal HI injury; leaves open translation to human neonates before clinical use.
Do early changes in heart rate variability and heart rate patterns indicate the severity of acute hypoxia-ischaemia in near-term fetal sheep?
Sinusoidal heart rate patterns and elevated vasopressin levels in the first hour after hypoxia-ischaemia may serve as early biomarkers of severe injury and subsequent loss of EEG power.
Kasai et al. (2019) studied this question.
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