Key result
A decrease in white blood cell count of 1,000/cu mm was associated with a 14% decreased risk for CHD death, independent of baseline WBC and other risk factors.
Why the study?
Does white blood cell count predict fatal and nonfatal coronary heart disease, cancer, and all-cause mortality in middle-aged men?
Population
6,222 middle-aged men, subset of participants in the Multiple Risk Factor Intervention Trial (MRFIT)
Design
Cohort
Authors
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WBC trends should not yet guide CHD management; extends observational links to mortality but leaves causal questions open.
Cohort (n=6,222)
Does white blood cell count predict fatal and nonfatal coronary heart disease, cancer, and all-cause mortality in middle-aged men?
Effect estimate: 14% decrease in risk
Higher white blood cell count is a significant, independent predictor of coronary heart disease and cancer mortality in middle-aged men, independent of smoking status.
Richard H. Grimm (1985) conducted a cohort in Coronary heart disease, cancer, and all-cause mortality (n=6,222). White blood cell count (WBC) was evaluated on Fatal and nonfatal coronary heart disease (CHD) incidence and all-cause and cancer mortality (14% decrease in risk). A decrease in white blood cell count of 1,000/cu mm was associated with a 14% decreased risk for CHD death, independent of baseline WBC and other risk factors.
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