Key result
Women lose their ASCVD risk advantage over men by their seventh decade.
Why the study?
Women lose their clinical advantage over men regarding atherosclerotic cardiovascular disease morbidity and mortality as they age, prompting review of the underlying hormonal, morphological, and physiological mechanisms.
This review discusses the mechanisms, including hormonal, morphological, and physiological differences, underlying the gender differences in vascular aging and coronary artery disease pathophysiology.
May prompt age-specific ASCVD risk reassessment in women; leaves open precise hormonal mechanisms.
Women have a clinical advantage over men in relation to atherosclerotic cardiovascular disease (CVD) (morbidity and mortality). This advantage disappears once women become older, and in their seventh decade, the risk to develop CVD equals men at that age. There have been several theories about this gender difference that were related to hormones, and the different morphology and physiology that characterize the cardiovascular system in women. In this review, the different mechanisms will be reviewed and discussed.
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Arnon Blum (2023) conducted a review in Atherosclerotic cardiovascular disease (CVD). Women have a clinical advantage over men regarding atherosclerotic cardiovascular disease risk, which disappears by their seventh decade when risk equals that of men.
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