Noninvasive imaging and provocative tests are essential for evaluating the unique spectrum of ischemic heart disease in women, which often involves microvascular dysfunction without obstructive epicardial disease.
This review emphasizes that ischemic heart disease in women encompasses a spectrum including microvascular dysfunction, necessitating sex-specific diagnostic strategies and appropriate use of noninvasive imaging modalities.
Evolving knowledge regarding sex differences in coronary heart disease has demonstrated that the prevalence, symptomatology, and pathophysiology of coronary atherosclerosis vary between genders. Women experience higher mortality rates and more adverse outcomes after acute myocardial infarction than men, despite a lower prevalence of obstructive coronary artery disease. Based on recent insights into the complex pathophysiology of coronary heart disease which includes a spectrum of obstructive coronary artery disease and dysfunction of the coronary microvasculature and endothelium, the term ischemic heart disease is a more accurate term for discussion of coronary atherosclerosis specific to women. In women, with clinical features and risk factors for ischemic heart disease, the detection and evaluation of ischemic heart disease is challenging due to the diverse pathogenic mechanisms of ischemic heart diseases in women. In this article, we discuss noninvasive imaging tests, provocative tests, including exercise testing in women with suspected ischemic heart disease.
Vavas et al. (Sun,) conducted a review in Suspected Coronary Artery Disease / Ischemic Heart Disease. Noninvasive imaging and provocative tests was evaluated. Noninvasive imaging and provocative tests are essential for evaluating the unique spectrum of ischemic heart disease in women, which often involves microvascular dysfunction without obstructive epicardial disease.