Key result
Pre-operative BNP levels predicted new postoperative cardiac events with an area under the curve of 0.85 (CI 0.72-0.98, p=0.001), where a value >170 pg/ml had 82% sensitivity and 79% specificity.
Why the study?
Does pre-operative BNP level predict postoperative cardiac events and mortality in patients undergoing major emergency non-cardiac surgery?
Population
40 patients undergoing major emergency non-cardiac surgery
Design
Cohort
Follow-up
6 months
Authors
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May support preoperative BNP for risk stratification in emergency noncardiac surgery; hypothesis-generating and requires prospective validation.
Observational (n=40)
Does pre-operative BNP level predict postoperative cardiac events and mortality in patients undergoing major emergency non-cardiac surgery?
Effect estimate: AUC 0.85 (95% CI 0.72-0.98)
p-value: p=0.001
Pre-operative BNP levels > 170 pg/ml show good sensitivity and specificity for predicting early postoperative cardiac events in patients undergoing major emergency non-cardiac surgery.
Cuthbertson et al. (2007) conducted an observational in Major emergency non-cardiac surgery (n=40). Pre-operative B-type natriuretic peptide (BNP) levels was evaluated on New postoperative cardiac event, and/or development of significant ECG changes, and/or cardiac death (AUC 0.85, 95% CI 0.72-0.98, p=0.001). Pre-operative BNP levels predicted new postoperative cardiac events with an area under the curve of 0.85 (CI 0.72-0.98, p=0.001), where a value >170 pg/ml had 82% sensitivity and 79% specificity.
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