Why the study?
Does a loss-of-function mutation in the NKX2.5 gene increase susceptibility to familial atrial fibrillation?
Does a loss-of-function mutation in the NKX2.5 gene increase susceptibility to familial atrial fibrillation?
A novel loss-of-function mutation in the NKX2.5 gene (p.F145S) is associated with increased susceptibility to familial atrial fibrillation, highlighting the role of abnormal cardiovascular development in AF pathogenesis.
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Supports NKX2.5 variants in familial AF pathogenesis; leaves open screening utility pending validation.
Huang et al. (2013) studied this question.
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