Surface Hydration and Antifouling Activity of Zwitterionic Polymers

It is believed that the strong surface hydration of zwitterionic polymers leads to excellent antifouling properties. This Perspective presents the recent developments in studies on such surface hydration in situ using sum frequency generation (SFG) vibrational spectroscopy. SFG research provides direct molecular level evidence that zwitterionic polymers have strong surface hydration, which prevents protein adsorption and marine animal attachment. The salt effect and protein interaction on surface hydration of zwitterionic polymers have also been examined using SFG. Possible future research directions on surface hydration of new zwitterionic polymers including zwitterionic hydrogels, copolymers, and mixed charged polymers are discussed. It is also important to combine experimental SFG studies with computer simulations to further elucidate the surface hydration to understand antifouling mechanisms.