Answers are grounded in this paper and cite their sources.
Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented.
No takes yet. Share an insight, caveat, or question.
Drouin et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: