Key result
PVI restores LVEF in ~53% of AF patients with LV dysfunction, with LGE predicting persistent impairment.
Why the study?
Does the presence of late gadolinium enhancement predict nonrecovery of left ventricular systolic function in patients with atrial fibrillation and LV dysfunction undergoing pulmonary vein isolation?
Cohort (n=172)
Does the presence of late gadolinium enhancement predict nonrecovery of left ventricular systolic function in patients with atrial fibrillation and LV dysfunction undergoing pulmonary vein isolation?
The absence of late gadolinium enhancement on CMR and freedom from AF recurrence are strong predictors of LVEF recovery after pulmonary vein isolation in patients with AF and LV dysfunction.
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LGE on CMR was associated with persistent LV dysfunction after PVI; leaves open whether imaging refines ablation selection in AF with reduced LVEF.
Addison et al. (2016) conducted a cohort in Atrial fibrillation and left ventricular systolic dysfunction (n=172). Late gadolinium enhancement (LGE) vs. Absence of LGE was evaluated on Recovery of LVEF defined as an EF >50%. Among patients with atrial fibrillation and LV dysfunction undergoing pulmonary vein isolation, 53% achieved LVEF recovery, with late gadolinium enhancement strongly predicting persistent dysfunction.
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