October 1, 1998Open Access

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

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Gregg L. Semenza (Thu,) studied this question.

synapsesocial.com/papers/6a0514c46c3d07813971be49 https://doi.org/https://doi.org/10.1016/s0959-437x(98)80016-6

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1Nucleotide Sequence, Chromosomal Assignment and mRNA Expression of Mouse Hypoxia-Inducible Factor-1α1996 · 122 citations
2Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 11995 · 172 citations
3Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit1996 · 1,189 citations
4HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels1997 · 370 citations
5Cardiac Expressions of HIF-1α and HLF/EPAS, Two Basic Loop Helix/PAS Domain Transcription Factors Involved in Adaptative Responses to Hypoxic Stresses1997 · 47 citations

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