Review of Osteosarcoma and Current Management

Figures

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  Fig. 1. AP (a) and lateral (b) X-rays of an 11-year-old patient with an osteosarcoma of the distal femur. Note the wide zone of transition, discontinuous periosteal reaction, and areas of increased mineralization

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  Fig. 2. MRI images from the patient in Fig. 1. a Coronal images showing the extent of the marrow abnormality and the soft-tissue mass which appears hypointense on T1 imaging. b STIR imaging illustrating the reaction zone of peritumoral inflammation. c, d Axial images through the tumor reveal a large soft tissue mass with surrounding edema. Pre- (e) and post-contrast (f) axial images show areas of enhancement in the bone and soft tissue, corresponding to sites of increased metabolic activity

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  Fig. 3. Medium-power (a) and high-power (b) microscopic images of an osteosarcoma specimen, showing high cellularity, nuclear polymorphism, atypia, and disorganized osteoid production

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  Fig. 4. X-ray (a) and MRI (b) of the distal femur of a 13-year-old girl, showing a large solitary lesion. However, staging with bone scan (c) and MRI (d) revealed additional skip metastasis in her ipsilateral femur diaphysis and peritrochanteric area that was not detected with initial imaging. The presence of the skip metastases changed the surgical plan from a distal femur resection to an entire femur resection and reconstruction (e)

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  Fig. 5. A 22-year-old male with an osteosarcoma of the proximal tibia. XR images (a) show an aggressive lesion of the proximal tibia with abundant osseous matrix. Resection of the tumor mass was performed with care taken to spare the neurovascular bundle (b), and then the defect was reconstructed with a proximal tibia endoprosthesis (c) and a medial gastrocnemius muscle flap for soft-tissue coverage (d). Resected tumor specimen (e, f) and gross pathology examination

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  Fig. 6. An 11-year-old male patient with a large osteosarcoma of the distal femur that was reconstructed with an expandable endoprosthesis. Preop (a), immediate postop (b), and 2-year postoperative (c) X-ray images are shown. A lengthening of almost 5 cm was achieved with the expandable construct by age 13

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  Fig. 7. 17-year-old male with periosteal osteosarcoma. MRI images (a, b) show the cortically based tumor is located in the metaphysis with some invasion of the marrow and a soft-tissue mass. A polyhedral, metaphysis-sparing bone cut was planned with navigation software (c), and intraoperative guidance was used to assist with the bone cuts according to the preoperative plan (d). A matching allograft was used to fill the defect and fixed to the patient’s remaining bone (e). Two-year follow-up shows robust union at the junction sites (f)