March 1, 2023Cell Reports88 citationsOpen Access

Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

CYCheng-Cheng Yao RSRui-ming Sun YYYi Yang

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Abstract

T cells through reprogramming glucose metabolism, making BCAAs alternative supplementary components to increase the clinical efficacy of anti-PD-1 immunotherapy against tumors.

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Yao et al. (Wed,) studied this question.

synapsesocial.com/papers/6a053337ccdd74096c3452d4 https://doi.org/https://doi.org/10.1016/j.celrep.2023.112186

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5Tumor-Induced Impairment of TCR Signaling Results in Compromised Functionality of Tumor-Infiltrating Regulatory T Cells2008 · 27 citations

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