Key result
The authors call for global enrollment of patients with calmodulin variants into the International Calmodulinopathy Registry to improve risk stratification and clinical management.
A call to action for physicians worldwide to enroll patients with calmodulinopathies into the International Calmodulinopathy Registry to improve risk stratification and management.
genes cause severe forms of long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, or idiopathic ventricular fibrillation, and there are many open questions concerning management and underlying mechanisms. What is currently known depends largely on the initial publications from the International Calmodulinopathy Registry. However, progress is delayed because the accrual of patients in the International Calmodulinopathy Registry is slow. As we did long ago for long QT syndrome, this is a call for action, requesting doctors all over the world to enroll even their isolated cases in the registry. This is the only way to obtain, for an adequate number of patients, the data necessary to define the spectrum of clinical manifestations and the genotype-phenotype correlation essential for an improved risk stratification and best therapeutic management. If you are willing to contribute, please contact us.
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Schwartz et al. (2025) conducted an editorial in Calmodulinopathies. International Calmodulinopathy Registry (ICamR) enrollment was evaluated. The authors call for global enrollment of patients with calmodulin variants into the International Calmodulinopathy Registry to improve risk stratification and clinical management.
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