Key result
Low TAPSE predicts arrhythmia-induced cardiomyopathy and worse quality of life after rhythm restoration in LVSD.
Why the study?
Arrhythmia-induced cardiomyopathy is an underrecognized cause of left ventricular systolic dysfunction, but its relationship with right ventricular function and quality of life has not been well studied.
Does right ventricular systolic dysfunction predict recovery of left ventricular systolic function and quality of life in patients with arrhythmia-induced cardiomyopathy?
Observational (n=50)
Does right ventricular systolic dysfunction predict recovery of left ventricular systolic function and quality of life in patients with arrhythmia-induced cardiomyopathy?
Answers are grounded in this paper and cite their sources.
In patients with arrhythmia-induced cardiomyopathy, right ventricular dysfunction is common, and low TAPSE predicts the diagnosis of AIC and correlates with worse quality of life.
INTRODUCTION: Arrhythmia-induced cardiomyopathy (AIC) is an underrecognized condition resulting in left ventricular systolic dysfunction (LVSD) that is primarily caused by atrial fibrillation (AFib). The relationship between AIC, right ventricular (RV) function, and quality of life (QoL) has not been well studied. METHODS: We performed a post-hoc analysis of our AIC trial in which we prospectively screened for patients with tachyarrhythmia and newly diagnosed, otherwise unexplained LVSD. Following rhythm restoration, patients were followed up at 2, 4, and 6 months. Only patients with persistent sinus rhythm were analyzed. RV function was assessed via echocardiography (tricuspid annular plane systolic excursion [TASPE] and fractional area change [FAC]) and QoL by the Minnesota Living with Heart Failure Questionnaire. RESULTS: Of a total of 50 patients recovering from LVSD, 41 were diagnosed with AIC and 9 with non-AIC. Initially, RV function was reduced in the AIC group and recovered after rhythm restoration, whereas no relevant changes were noted in the non-AIC group. QoL was reduced in both groups and also improved after rhythm restoration. Regression analysis identified low TAPSE as a predictive parameter for AIC diagnosis and worse QoL in AIC patients. CONCLUSION: We demonstrated that RV function and QoL are impaired in patients with AIC. Six months after rhythm restoration, TAPSE may serve as an early indicator of AIC while also correlating with QoL. This underscores the importance of detailed echocardiographic evaluation with a focus on RV function in patients with concomitant tachyarrhythmia and LVSD.
No takes yet. Share an insight, caveat, or question.
Körtl et al. (2025) conducted an observational in Arrhythmia-induced cardiomyopathy (n=50). Rhythm restoration vs. Non-AIC patients was evaluated on Right ventricular function (TAPSE and FAC) and quality of life. In patients with tachyarrhythmia and LVSD, low TAPSE predicted arrhythmia-induced cardiomyopathy diagnosis and worse quality of life following rhythm restoration.
Synapse has enriched 10 related papers. Consider them for comparative context: