Clinical and Immunological Features of Atopic Dermatitis Associated With Helminthic Invasions in Children Aged 3–7

This article provides a comprehensive analysis of helminthic infections widely prevalent in the pediatric population and their impact on the development and clinical phenotype of atopic dermatitis based on modern scientific approaches. Parasitic diseases have a high global prevalence and pose a significant threat to children's health, especially in regions with inadequate sanitary and hygienic conditions. The study examines the effects of helminth infections on the host immune system, with particular emphasis on the predominance of T-helper 2 (Th2) immune response, increased immunoglobulin E (IgE) production, and activation of eosinophilic granulocytes, all of which contribute to the pathogenesis of atopic dermatitis. The findings are systematized to provide a deeper understanding of immunopathological mechanisms underlying the interaction between parasitic infections and allergic diseases in children.