Autologous Induced Cloning (AIC) Technology: Blueprint Construction, Existing Gaps, and Application Prospects

Somatic cell nuclear transfer (SCNT) has inherent defects such as epigenetic reprogramming disorders and low cloning efficiency, which can hardly meet the sustainable demand of improved varieties in animal husbandry. This paper proposes the Autologous Induced Cloning (AIC) system, systematically expounds its technical principle, construction process and core advantages, analyzes the breakthroughs of AIC in solving SCNT epigenetic defects and telomere shortening, and prospects its application in breeding, germplasm conservation and disease-resistant breeding, providing a theoretical reference for the upgrading of animal cloning technology.This paper also systematically clarifies the current core technical gaps and future optimization directions of this technical system.Unlike traditional SCNT which relies on artificial forced reprogramming, AIC utilizes the inherent physiological programs of mammalian cells to achieve endogenous epigenetic resetting, providing a novel paradigm for animal cloning technology.