Super-resolution ultrasound imaging using microbubble and gas vesicles

Super-resolution ultrasound (SRUS), through localizing spatially isolated individual microbubbles, also known as ultrasound localization microscopy (ULM), has been shown to be able to break the wave diffraction limit and generate microscopic resolution at centimeter depth, offering great promises for a wide range of clinical applications. However, a number of technical challenges remain. In the talk I would introduce some of our efforts to better understand and address these challenges, and also show some initial efforts to generate super-resolution images of ex vivo cells expressing gas vesicles.