Cobalt-Catalyzed Reductive Carboxylation of Aldehydes/Ketones for the Synthesis of α-Arylalkanoic Acids

Yiding Liu; Xiaochen Niu; Hongwei Zhou

doi:10.1021/acs.orglett.6c01587

May 12, 2026Organic Letters

Cobalt-Catalyzed Reductive Carboxylation of Aldehydes/Ketones for the Synthesis of α-Arylalkanoic Acids

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Key Points

This study aims to develop a new method for synthesizing α-arylalkanoic acids using cobalt-catalyzed reductive carboxylation of aldehydes and ketones.
Utilized cobalt-catalyzed carboxylation sequence involving Pudovik reaction and phospha-Brook rearrangement.
Investigated plausible reaction mechanisms for improved understanding.
Successfully established a new protocol for the synthesis of α-arylalkanoic acids.
Identified effective catalytic conditions that enhance the reaction efficiency.

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Implication

Demonstrates efficient synthesis of α-arylalkanoic acids from aldehydes and ketones, suggesting a useful protocol for chemical production.

Abstract

as the starting materials was established. This protocol contains a sequence of Pudovik reaction, phospha-Brook rearrangement and cobalt-catalyzed carboxylation. The plausible mechanism of this reaction was investigated.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a056695a550a87e60a1e8db https://doi.org/10.1021/acs.orglett.6c01587

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Cobalt-Catalyzed Reductive Carboxylation of Aldehydes/Ketones for the Synthesis of α-Arylalkanoic Acids

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cobalt-Catalyzed Reductive Carboxylation of Aldehydes/Ketones for the Synthesis of α-Arylalkanoic Acids

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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