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May 14, 2026European Journal of Neuroscience

Comparison Effects of Anodal Versus Cathodal Trans‐Cranial Direct Current Stimulation Over Primary Motor Cortex on Lower Limb Muscles' Spasticity: A Randomized Clinical Trial Study

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Authors

RBRazieh BazghandiSemnan University of Medical SciencesCDCyrus Taghizadeh DelkhoshSemnan University of Medical SciencesSMSalimeh MahmoodiSemnan University of Medical Sciences

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Implication

Randomized trial compares muscle spasticity outcomes in stroke patients receiving different tDCS treatments, highlighting effectiveness of anodal stimulation.

Key Points

  • This research aims to compare the effects of anodal and cathodal transcranial direct current stimulation on muscle spasticity in stroke patients.
  • 39 patients were randomly assigned to three groups: affected M1 a-tDCS, unaffected M1 c-tDCS, and sham tDCS.
  • All groups received routine physiotherapy in addition to their assigned treatment.
  • Muscle activity and outcomes were assessed pre-treatment, immediately post-treatment, and 2 weeks later.
  • Tibialis anterior activity increased significantly in the affected M1 a-tDCS group after the intervention (p < 0.001).
  • Lateral gastrocnemius activity decreased, while MAS and WHOQOL scores improved immediately and 2 weeks after a-tDCS (p < 0.001).
  • These findings demonstrate the short-term efficacy of a-tDCS combined with physiotherapy in improving spasticity and quality of life.

Cite This Study

Bazghandi et al. (2026) studied this question.

synapsesocial.com/papers/6a056695a550a87e60a1e970https://doi.org/10.1111/ejn.70499
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke2005 · 484 citations
  2. 2Postural adjustment and muscle activity during each phase of gait initiation in chronic ankle instability: an observational study2024 · 3 citations
  3. 3Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation2019 · 137 citations
  4. 4Transcranial direct current stimulation and suppression of contralesional primary motor cortex post-stroke: a systematic review and meta-analysis2018 · 30 citations