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May 12, 2026Cancer Screening and PreventionOpen Access

Olink Proteomic Research in Colorectal Cancer: Redefining Minimally Invasive Surgery through Biomarker-driven Insights

Zhenting Zhao Nan Wang Pengyue Zhao

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Key Points

The research aims to explore the differences in plasma proteomics between two surgical techniques for colorectal cancer.
Utilized high-fidelity Olink proteomic profiling for analysis.
Performed a plasma proteomic comparison between Endoscopic Super-Minimally Invasive Surgery and laparoscopic surgery.
Identified candidate diagnostic and surgery-specific injury biomarkers.
Identified diagnostic biomarkers including AMN, LRP1, FOXO1, PTPRJ which may aid in diagnosis.
Found surgery-specific injury markers CALCA and PDGFC, implying their relevance in surgical outcomes.

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Implication

Compares outcomes of ESMIS and laparoscopic surgery in colorectal cancer, suggesting biomarker use for better insights.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a056695a550a87e60a1e9ce https://doi.org/10.14218/csp.2026.00029

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification of Biomarkers for Precancerous Colorectal Lesions Utilizing Olink Proteomics and Colorectal Cancer Animal ModelsOriginal Research · 2026
2Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology2024 · 2 citations
3Metabolomics and proteomics analyses reveal the potiental mechanisms underlying colorectal cancer and chemotherapy targetsOriginal Research · 2026
4Dissecting Non-Small Cell Lung Cancer (NSCLC) with Blood Proteomics - From Surgical to Immunotherapeutic Responses2025
5Abstract 936: Targeted proteomics and next-generation sequencing (NGS) for biomarker discovery in metastatic colorectal cancer (mCRC)2024

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