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May 14, 2026International Journal of Molecular SciencesOpen Access

Pla2g6 Deficiency Induces Neuronal Precursor Apoptosis During Neurodevelopment

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Authors

YSYang-Jin ShenHLHan-Fang LiuTHTing-Chen Hsu

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Overview

Randomized trial investigates Pla2g6's role in neurogenesis and apoptosis in zebrafish embryos, suggesting implications for neurodevelopmental disorders.

Key Points

  • The research aims to determine how PLA2G6 regulates neuronal precursor survival during neurodevelopment.
  • Used zebrafish embryos to explore Pla2g6's role in neural development via loss- and gain-of-function approaches.
  • CRISPR/Cas9-mediated gene editing performed to study the effects of Pla2g6 deficiency.
  • Assessed apoptosis and proliferation rates among neuronal precursors.
  • Pla2g6 deficiency significantly reduced neuronal precursors without affecting their proliferation.
  • Increased apoptosis was identified as a mechanism for reduced neuronal precursor survival.
  • Pla2g6 overexpression mitigated oxidative stress-induced apoptosis, highlighting its protective role.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/6a0566bda550a87e60a1ea36https://doi.org/10.3390/ijms27104280
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