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May 14, 2026BMJ OpenOpen Access

Protocol for a single-blind, single-centre, parallel-group, non-inferiority randomised controlled trial: comparison of oxygenation stability between different ventilators in mechanically ventilated patients during intrahospital and interhospital transport

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Authors

SJShouyin JiangMYMinfei YangHWH M Wang

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Overview

Randomized trial evaluates oxygenation stability in mechanically ventilated patients during transport, indicating potential choice of ventilator.

Key Points

  • This trial aims to evaluate whether the Mindray TV80 ventilator maintains oxygenation stability as effectively as the Hamilton T1 during patient transport.
  • Single-blind, single-centre, parallel-group, non-inferiority randomized controlled trial.
  • Participants aged 18–80 undergoing intrahospital or interhospital transport will be randomized 1:1 to either TV80 or Hamilton T1.
  • Primary outcome is the difference in oxygenation index before and after transport, with continuous monitoring of SpO₂.
  • Sample size of 98 (49 per group) determined for 80% power and non-inferiority margin of −30 mm Hg.
  • Subgroup analyses will assess outcomes by transport type (intrahospital vs interhospital).
  • Secondary outcomes include changes in respiratory parameters and the incidence of adverse events.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a0566bda550a87e60a1eb24https://doi.org/10.1136/bmjopen-2025-111661
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