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May 14, 2026BMC MicrobiologyOpen Access

Susceptibility to novel antimicrobial agents and molecular epidemiology of carbapenem-resistant enterobacterales: a 9-year study in Central China

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Authors

YHYungang HanZhengzhou UniversityQWQi WangPeking UniversityHCHC ChenZhengzhou University

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Implication

Surveillance study evaluates susceptibility of novel antimicrobial agents in Central China, indicating urgent infection control needs.

Key Points

  • The study aims to explore the molecular epidemiology and susceptibility of carbapenem-resistant Enterobacterales in Central China.
  • Conducted antimicrobial susceptibility testing using broth microdilution
  • Selected 133 representative strains from 1,403 CRE isolates for molecular analysis
  • Performed PCR and sequencing for carbapenemase genes and multilocus sequence typing
  • Cefiderocol and aztreonam-avibactam showed 100% susceptibility against tested CRE strains
  • Among CRKP isolates, susceptibility rates to ceftazidime-avibactam, imipenem-relebactam, and meropenem-vaborbactam were 92.7%, 96.4%, and 97.3% respectively
  • The CRKP-ST11-blaKPC-2 clone was identified as the primary disseminator with 81.2% predominance.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6a0566bda550a87e60a1ebadhttps://doi.org/10.1186/s12866-026-05160-y
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