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May 14, 2026Current Computer - Aided Drug Design

Integrating Multi-omics, Mendelian Randomization, and ExperimentalValidation to Unveil the Role of Traditional Chinese Medicine inPostmenopausal Osteoporosis

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Authors

HXHefang XiaoYWY WangYCYuehua Chen

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Overview

Randomized trial investigates traditional Chinese medicine's mechanism in postmenopausal osteoporosis, suggesting targeted therapeutic benefits.

Key Points

  • This study aims to uncover the mechanisms through which traditional Chinese medicine affects postmenopausal osteoporosis.
  • Analyzed bulk transcriptome and single-cell RNA sequencing data using various bioinformatics approaches.
  • Utilized Mendelian randomization with the TwoSampleMR package to establish causal relationships.
  • Performed molecular docking to validate drug-target interactions involving CTNNB1.
  • Identified five critical genes associated with PMOP, with AUC values above 0.7, suggesting their importance in disease progression.
  • Mendelian randomization showed a causal relationship between CTNNB1 and osteoporosis (OR=0.950, P=6.45E-17).
  • Animal PCR results confirmed the expression of CTNNB1, highlighting its role in the therapeutic effects of TCM.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a0566d9a550a87e60a1ec47https://doi.org/10.2174/0115734099401120251101190026
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