Clinical Evaluation of Immunological and Hepatic Alterations in Amphetamine-Dependent Patients

Amphetamine is a chemical compound that changed into synthetic through the Romanians inside the year 1887. This compound has a very robust effect on the nervous and mental system and has bad consequences on the cardiovascular system, in addition to bad consequences on the heart, liver, kidneys, and different organs of the body. Amphetamine is a useful psychostimulant, but when abused, it damages serotonin and dopamine receptors. Among the most significant side effects of amphetamine usage are weakened immunity and increased inflammation. Lepoxin, an immunological and anti-inflammatory indicator, was selected as one of the biochemical parameters because its results indicated a drop in the blood level of amphetamine abusers. In this study, sixty participants served as a case study, while sixty others served as a control group. All of the samples were obtained from the Basra Governorate’s Al-Fayhaa Hospital. The study concentrated on the liver enzymes AST, ALP, GGT, and TSB, as well as the immunological factor represented by lipoxin. For lipoxin, the concentrations were determined using the ELISA method; for the remaining biochemical parameters, spectrometry was used. There was no discernible difference between the amphetamine abusers and the control group, according to the findings of the search for liver enzymes, GGT, and TSB. This may be attributed to the duration of the abusers’ use as well as the dosage concentration. However, the findings indicate that the case group’s lipoxin levels were much lower than those of the control group. We determine that the reaction of liver enzymes, bilirubin, and GGT, is less responsive to lipoxin than the immunological and inflammatory response. We advise carrying out a more accurate laboratory survey of drug users, accounting for the user’s age and weight, the concentration administered, and the duration of usage.