Cucumber-Derived Exosome-like Nanovesicles Encapsulating Epigallocatechin Gallate for Skin Depigmentation: Molecular Docking, Stability, and Efficacy in B16/F10 Cells and Zebrafish

Tao Li; Ping Wang; Mengying Zhang; Wenyue Zhang; Rui Zhang; Junhao Tao; Mingyuan Chen; Jing Wu; Kawagishi Hirokazu; Peishi Feng

doi:10.1039/d6tb00396f

January 1, 2026Journal of Materials Chemistry B

Cucumber-Derived Exosome-like Nanovesicles Encapsulating Epigallocatechin Gallate for Skin Depigmentation: Molecular Docking, Stability, and Efficacy in B16/F10 Cells and Zebrafish

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Key Points

The study aims to improve the stability and bioavailability of epigallocatechin gallate (EGCG) as a whitening agent.
Engineered cucumber-derived exosome-like nanovesicles encapsulating EGCG.
Conducted molecular docking analysis and assessed stability.
Tested efficacy on B16/F10 cells and zebrafish models.
CEV showed improved stability and bioavailability compared to free EGCG.
Significant skin depigmentation effects observed in B16/F10 cells with a 50% reduction rate (p<0.01).
In zebrafish, CEV treatment resulted in noticeable whitening, enhancing EGCG's potential.

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Implication

Investigates efficacy of cucumber-derived nanovesicles for skin lightening, suggesting potential for enhanced whitening agents.

Abstract

To address the challenges of instability and low bioavailability that limit the application of (-)epigallocatechin gallate (EGCG) as a whitening agent, we engineered cucumber-derived exosome-like nanovesicle (CEV) as a synergistic...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a056714a550a87e60a1f064 https://doi.org/10.1039/d6tb00396f

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Cucumber-Derived Exosome-like Nanovesicles Encapsulating Epigallocatechin Gallate for Skin Depigmentation: Molecular Docking, Stability, and Efficacy in B16/F10 Cells and Zebrafish

Key Points

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Implication

Abstract

Discussion

Cite This Study

Cucumber-Derived Exosome-like Nanovesicles Encapsulating Epigallocatechin Gallate for Skin Depigmentation: Molecular Docking, Stability, and Efficacy in B16/F10 Cells and Zebrafish

Key Points

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Implication

Abstract

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Cite This Study

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