Design and optimization of a Cu-MOF@graphene oxide nanozyme for point-of-care colorimetric determination of sarcosine and H ₂ O ₂

Martin N. Saad; A H Mahmoud; Sawsan Amer; Ibrahim M. El‐Sherbiny; Hoda M. Marzouk

doi:10.1039/d6ra01609j

January 1, 2026RSC AdvancesOpen Access

Design and optimization of a Cu-MOF@graphene oxide nanozyme for point-of-care colorimetric determination of sarcosine and H ₂ O ₂

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Key Points

The aim is to design and optimize a Cu-MOF@graphene oxide nanozyme for detecting sarcosine and hydrogen peroxide.
Developed a Cu-MOF/graphene oxide nanozyme
Optimized through a CCD (Central Composite Design) approach
Focused on point-of-care colorimetric detection
Achieved ultrasensitive detection of sarcosine and H2O2
Demonstrated high specificity in on-site applications
Provided a novel solution for colorimetric analysis

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Implication

Demonstrates ultrasensitive determination of sarcosine and H2O2 in colorimetric assays, suggesting improved point-of-care diagnostics.

Abstract

First report of a Cu-MOF/graphene oxide nanozyme, CCD-optimized, enabling ultrasensitive and specific on-site colorimetric sarcosine and H 2 O 2 determination.

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Saad et al. (2026) studied this question.

synapsesocial.com/papers/6a056714a550a87e60a1f1a1 https://doi.org/10.1039/d6ra01609j

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Design and optimization of a Cu-MOF@graphene oxide nanozyme for point-of-care colorimetric determination of sarcosine and H ₂ O ₂

Key Points

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Implication

Abstract

Discussion

Cite This Study

Design and optimization of a Cu-MOF@graphene oxide nanozyme for point-of-care colorimetric determination of sarcosine and H ₂ O ₂

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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